In this episode, Anna explores the current evidence surrounding creatine supplementation in Long Covid and fatigue-related conditions, including its potential role in energy metabolism, muscle function, cognitive symptoms, nervous system health, and recovery capacity.

This conversation also looks at:

• Why creatine is being investigated in Long Covid
• The link between ATP production and fatigue
• Potential neuroprotective and antioxidant mechanisms
• Brain fog and cognitive symptoms
• Muscle weakness, PEM, and pacing considerations
• Why individual responses to supplements can vary
• Considerations around dosage, safety, and supplement sensitivity
• Creatine and the menstrual cycle

Importantly, this episode takes a balanced and non-dogmatic approach. While early research is promising, creatine is not presented as a “magic bullet” or standalone solution for Long Covid.

As always, recovery is complex, individual, and multifactorial.

This episode is intended for educational purposes only and should not replace personalised medical advice.

Useful Links

Take the Chronic Fatigue Quiz: https://app.annamarsh.co.uk/quiz-page

Instagram: https://www.instagram.com/anna__marsh_

Work with me: https://annamarsh.co.uk/work-together/

Website: https://annamarsh.co.uk/

Referenced Articles

Effects of six-month creatine supplementation on patient- and clinician-reported outcomes, and tissue creatine levels in patients with post-COVID-19 fatigue syndrome

Reduced tissue creatine levels in patients with long COVID-19: A cross-sectional study

Creatine Supplementation in Women’s Health: A Lifespan Perspective

Creatine Supplementation and Brain Health

Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome

Role of Creatine Supplementation in Conditions Involving Mitochondrial Dysfunction: A Narrative Review

What happens when the nervous system begins to reconnect with emotions, sensations, and internal experiences that were previously difficult to fully feel.

As the body becomes safer and more regulated, many people notice unexpected shifts:

• emotions feeling stronger or more accessible
• increased sensory awareness
• old feelings resurfacing
• a changing relationship with capacity, vulnerability, and self-protection.

Drawing from both personal experience and Somatic Experiencing concepts such as undercoupling and energy wells, Anna explores why these changes can emerge during recovery — and why they are often part of the nervous system recalibrating rather than “going backwards.”

This episode is a gentle conversation about the emotional and physiological complexity of healing, and the process of learning how to feel safely again.

Useful Links

Take the Chronic Fatigue Quiz: https://app.annamarsh.co.uk/quiz-page

Instagram: https://www.instagram.com/anna__marsh_

Work with me: https://annamarsh.co.uk/work-together/

Website: https://annamarsh.co.uk/

Rather than simply summarising the research, Anna walks you through what these findings may actually mean in practice. We’ll explore how glutamate fits into the wider picture of nervous system regulation, inflammation, and energy metabolism — and why these conditions can’t be understood through a single lens.

Anna talks about where targeted approaches like diet, supplements, or medication may have a role, and why addressing underlying drivers is often key to more meaningful, sustainable progress.

This episode is designed to help you make sense of the science — without oversimplifying it — and to offer a more integrated way of understanding your symptoms.

Useful Links

Take the Chronic Fatigue Quiz: https://app.annamarsh.co.uk/quiz-page

Instagram: https://www.instagram.com/anna__marsh_

Work with me: https://annamarsh.co.uk/work-together/

Website: https://annamarsh.co.uk/

This conversation gently explores the reality of rebuilding a life alongside ongoing symptoms — from the early confusion of becoming unwell, to navigating setbacks, identity shifts, and the emotional impact of recovery.

Together, they talk about the often-unspoken parts of the journey, including loneliness, the role of community, learning to set boundaries, and what it means to move forward when life looks very different to before.

They also explore the complexities of breakups and dating during recovery — how illness can shape identity, relationships, and self-perception, and the process of learning to trust yourself and others again.

This is an honest, grounded conversation about the messy middle of recovery — and the gradual, often quiet process of rebuilding a life that feels meaningful, supportive, and your own.

Useful Links

Find Lexi: https://www.instagram.com/_lexisophie/

Take the Chronic Fatigue Quiz: https://app.annamarsh.co.uk/quiz-page

Instagram: https://www.instagram.com/anna__marsh_

Work with me: https://annamarsh.co.uk/work-together/

Website: http://annamarsh.co.uk/

Join the Nurturing Resilience Subscription: https://annamarsh.co.uk/nurturing-resilience/

They may feel overwhelmed in busy environments, react strongly to caffeine, or find it difficult to switch off mentally after a demanding day.

Sometimes people encounter the term COMT when exploring genetic testing and begin to wonder whether this might explain their nervous system sensitivity.

But conversations about COMT online can quickly become confusing — and sometimes unnecessarily alarming.

In this episode, Anna explores what COMT actually does in the body, how it influences the way we process certain stress-related brain chemicals, and why some nervous systems naturally experience stimulation more strongly than others.

Most importantly, we discuss why COMT is not a defect, but rather a pattern of biological sensitivity that can have both challenges and strengths.

Useful Links

Take the Chronic Fatigue Quiz: https://app.annamarsh.co.uk/quiz-page

Instagram: https://www.instagram.com/anna__marsh_

Work with me: https://annamarsh.co.uk/work-together/

Website: http://annamarsh.co.uk/

Join the Nurturing Resilience Subscription: https://annamarsh.co.uk/nurturing-resilience/

You may be working again. Socialising more. Exercising gently. Participating in daily life in ways that once felt impossible.

And yet, your system may still experience occasional fluctuations.

Energy might dip after a busy week. Sleep may become more fragile during stressful periods. Your nervous system might still feel sensitive to certain types of load.

This stage can feel confusing, because you’re no longer severely ill — but things don’t always feel completely stable yet.

In this episode, Anna explores what she often describes as the fine-tuning phase of recovery.

At this stage the work often shifts away from major repair and toward calibrating how the body distributes load across daily life.

Understanding this phase can help reduce frustration and provide a clearer framework for navigating the final stages of recovery.

Useful Links

Take the Chronic Fatigue Quiz: https://app.annamarsh.co.uk/quiz-page

Instagram: https://www.instagram.com/anna__marsh_

Work with me: https://annamarsh.co.uk/work-together/

Website: http://annamarsh.co.uk/

Join the Nurturing Resilience Subscription: https://annamarsh.co.uk/nurturing-resilience/

Many people have been told to exercise more. Others have experienced crashes after pushing too hard. And over time, movement itself can start to feel risky.

But something interesting often emerges during recovery.

Certain types of gentle, rhythmic movement can actually help the nervous system settle.

In this episode, Anna explores why the body sometimes responds positively to movement — not because it improves fitness, but because it can help the nervous system process activation and return toward regulation.

This episode also introduces the idea that movement can support the body in discharging and organising sympathetic activation, which can reduce internal agitation and support nervous system balance.

Useful Links

Take the Chronic Fatigue Quiz: https://app.annamarsh.co.uk/quiz-page

Instagram: https://www.instagram.com/anna__marsh_

Work with me: https://annamarsh.co.uk/work-together/

Website: http://annamarsh.co.uk/

Join the Nurturing Resilience Subscription: https://annamarsh.co.uk/nurturing-resilience/

And many people immediately think:

"I’m back where I started."

But in many cases, what looks like a relapse is actually something quite different.

Sometimes the body is simply going through a temporary recalibration.

In this episode, Anna explores why symptom waves can occur even after months or years of improvement, and why these experiences often don’t mean that progress has been lost.

Understanding the difference between a true relapse and a temporary recalibration can reduce a huge amount of fear and help people respond more calmly when fluctuations occur.

Useful Links

Take the Chronic Fatigue Quiz: https://app.annamarsh.co.uk/quiz-page

Instagram: https://www.instagram.com/anna__marsh_

Work with me: https://annamarsh.co.uk/work-together/

Website: http://annamarsh.co.uk/

Join the Nurturing Resilience Subscription: https://annamarsh.co.uk/nurturing-resilience/

In this episode, Anna breaks down the three most common patterns of post-exertional crashes seen in clinical practice: autonomic “hit the wall” crashes, metabolic “wired but exhausted” responses, and delayed immune-driven flares.

You’ll learn why timing matters, how different symptom patterns reflect different underlying mechanisms, and why applying the wrong strategy can stall progress.

This is not about avoiding movement or labelling yourself as fragile. It’s about understanding your physiology well enough to work with it.

If you’ve ever felt confused by your crashes — or wondered why generic pacing advice hasn’t quite worked for you — this episode will offer clarity.

Complimentary Episode:

Episode 146: Research Review - The PEM puzzle

Resources

Take the Chronic Fatigue Quiz: https://app.annamarsh.co.uk/quiz-page

Instagram: https://www.instagram.com/anna__marsh_

Work with me: https://annamarsh.co.uk/work-together/

Website: http://annamarsh.co.uk/

Join the Nurturing Resilience Subscription: https://annamarsh.co.uk/nurturing-resilience/

Join Nurturing Resilience: https://annamarsh.co.uk/nurturing-resilience/

Useful Links

Take the Chronic Fatigue Quiz: https://app.annamarsh.co.uk/quiz-page

Instagram: https://www.instagram.com/anna__marsh_

Work with me: https://annamarsh.co.uk/work-together/

Website: http://annamarsh.co.uk/